研究人员通过增加特定的生长因子和小分子，模仿体内复杂的细胞环境，实现了在类器官中自我更新和分化的动态平衡。优化后的人类肠道类器官在保持细胞快速增殖的同时，细胞类型也得到了显著拓展。更重要的是，研究团队通过不同的环境因子组合，探索了细胞在分化过程中的多 ...

▎药明康德内容团队编辑（来源：同济大学）成体干细胞来源的类器官是一种重要的体外研究工具，能够高度模拟体内组织的发育、稳态维持和再生过程。凭借其接近体内真实环境的细胞组成、组织结构及功能特征，类器官已成为研究发育机制、疾病发生发展以及药物筛选的重要平台 ...

A human intestinal organoid, displaying typical ‘budding crypts’ and a central ‘villus-like’ domain. The main intestinal cell types are shown in green, blue, red and purple. Membranes are ...

Our approach to organoid culture and differentiation involves the use of synthetic matrices to direct morphogenesis through tunable biochemical and mechanical signals. We spatiotemporally pattern ...

Caption Organoid of a patient with colon cancer, treated (right) and not treated with the chemotherapy etoposide. The treatment causes DNA damage and a reduction in protein synthesis. This ...

Key to this research is the use of state-of-the-art human intestinal organoid cultures. Obtained from diverse donors, these cultures provide a physiologically relevant and genetically representative ...

The lab is also interested in the genomic basis of infectious diseases and in understanding how the intestine repairs following infection. The use of intestinal organoid cultures is a foundation for ...

We offer diverse products and services, including cardiac disease modeling, organoid identification, and drug screening ... our brain organoids enhance understanding and advance disease modeling and ...

Cdx2 loss in mouse proximal colon organoid recapitulates gene expression patterns of human colon cancers with low CDX2 expression. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024 ...