研究人员通过增加特定的生长因子和小分子，模仿体内复杂的细胞环境，实现了在类器官中自我更新和分化的动态平衡。优化后的人类肠道类器官在保持细胞快速增殖的同时，细胞类型也得到了显著拓展。更重要的是，研究团队通过不同的环境因子组合，探索了细胞在分化过程中的多 ...

▎药明康德内容团队编辑（来源：同济大学）成体干细胞来源的类器官是一种重要的体外研究工具，能够高度模拟体内组织的发育、稳态维持和再生过程。凭借其接近体内真实环境的细胞组成、组织结构及功能特征，类器官已成为研究发育机制、疾病发生发展以及药物筛选的重要平台 ...

Key to this research is the use of state-of-the-art human intestinal organoid cultures. Obtained from diverse donors, these cultures provide a physiologically relevant and genetically representative ...

An organoid was then transplanted into the colon of the patient using an endoscope – a minimally invasive procedure. In previous experiments using this method in mice, the team confirmed that ...

The lab is also interested in the genomic basis of infectious diseases and in understanding how the intestine repairs following infection. The use of intestinal organoid cultures is a foundation for ...

Intestinal cells, for example ... the Invasin protein from Yersinia bacteria can be used as key component for organoid culture. Credit: Sensu. Hubrecht Institute. The possibility of culturing ...

Organoid technology has lately risen to prominence as a critical tool for both basic and biomedical research. Embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and primary ...

Dr Gianmaria Liccardi A organoid of intestinal tissue Previous attempts to predict how patients would respond to treatment included making "cancer avatars" - essentially mice with the patient's ...

Researchers from the Organoid group have developed a novel ... “We were able to grow and maintain organoids long term from human intestinal and airway cells, mouse intestinal cells, and even ...

Researchers analyzed organoid clinical characteristics ... which may contribute to impaired intestinal function. Pacritinib ...