If your nerve pain is chronic or severe, you’ll likely need prescription-strength medications because common OTC medications, like ibuprofen, aspirin, and acetaminophen aren’t very effective ...

[92] Onabotulinum toxin-A is approved for headache prophylaxis in adults with chronic migraine and has approximately the same rate of improvement. Side effects of PAM drugs should be reviewed ...

Chronic migraine becomes “refractory” when preventive treatments don’t work to reduce the frequency of episodes. Treatment may include complementary therapies like neuromodulation.