Under this two-hit model, Brugge says, one normal copy of BRCA1 ought to be able to carry out DNA repair even when the other ...

A new study in mice explains how even a single faulty copy of the BRCA1 gene can fuel tumor growth. The findings suggest the dominant “two-hit” hypothesis of cancer development may not tell the full ...

People inherit two copies of each gene — one from each parent — an evolutionary fail-safe to ensure survival even when one of ...

Reseachers from WEHI (Melbourne, Australia) have found a new way to predict a subset of patients who are likely to become ...

TOP1 is the target of topotecan, which was approved in 1997 by the U.S. Food and Drug Administration (FDA) to treat relapsed ...

Medically reviewed by Adam M. Brufsky, MD, PhD The exact cause or causes of triple-negative breast cancer are unknown, but ...

A new study finds that pathogenic germline variants (PGVs) in cancer predisposition genes like BRCA1 and BRCA2 increase the risk of multiple ...

Many people are familiar with the BRCA1 and BRCA2 mutations which predispose to breast cancer. These genes are referred to as tumor suppressor genes which code for proteins that control the repair of ...

Nov. 11, 2024 — A new database covering over 100 different canine tissues can significantly enhance our understanding of hereditary diseases and provide valuable information for health research ...