Emapalumab is a monoclonal antibody that neutralises interferon gamma (IFN?), a key cytokine which contributes to the inflammation and ... in a session entitled "Efficacy and Safety of emapalumab in ...

Cytokine and chemokine serum levels were detected using the MILLIPLEX kit (EMD MILLIPORE) as per manufacturer’s instructions and fold changes were calculated between clodronate treated and untreated ...

In M2 macrophages ... from untreated patients (Figures 4B, C). After differentiation into M2 macrophages, the cells were treated with antibodies against the subunits of IL-4R type I (IL-4Rα; dupilumab ...

This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (K Suzuki and N Ishii), a Grant-in-Aid for ...

25 Monocytes and macrophages can be activated through various pathways, including pattern recognition receptors responding to PAMPs and DAMPs, and stimulation by IFN-γ. 26 IL-1β is recognised as a ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Macrophages fight infection and ensure tissue ...

Their analysis revealed about 7% of all dementia cases can be tied to high LDL cholesterol in midlife, and 2% of cases can be linked to untreated ... mental stimulation, and social engagement ...

Monocytes and macrophages are myeloid cells that have important innate immune functions. Macrophages reside in tissues and respond to infection by producing inflammatory mediators and engulfing ...

S.G. Waxman is the Bridget Flaherty Professor ... a mouse model of MS Sodium channels regulate the function of macrophages and microglia, so, in addition to a direct protective effect on axons ...

As a result of this restraint, he says, he sustained a fracture in his right arm and staff allegedly left his injuries untreated for 24 hours. He said he suffered further physical assaults in ...