Immunotherapy is based on harnessing a person's own immune system to attack cancer cells. However, patients with certain tumors do not respond to these therapies and it remains unclear why.

Immunotherapy, cancer treatments that alter the immune system, making it better apt to fight tumor cells, have provided novel ...

Based on early studies, it was hypothesized that expression of Fas ligand (FasL) by tumor cells enabled them to counterattack the immune system, and that transplant rejection could be prevented by ...

However, as tumors evolve, they exploit the TIME to ... thereby influencing processes like immune escape, angiogenesis, and metastasis. HCC is particularly adept at manipulating the TIME via ...

Immunotherapy is a treatment that strengthens the ability of the patient’s own immune system to detect and destroy cancer. Cancer cells often have mutations that allow them to escape the immune system ...

Many of the cells in the innate immune system produce cytokines or interact with other cells directly to activate the adaptive immune system. In cancer cells, mutations can lead to expression of tumor ...

A group of immune proteins called the inflammasome can help prevent blood stem cells from becoming malignant by removing certain receptors from their surfaces and blocking cancer gene activity, ...

Researchers at Karolinska Institutet and the Astrid Lindgren Children's Hospital in Sweden have determined how children's ...

The new technique could kill a wide range of cancer cells, including breast and prostate A newly-discovered part of our immune system could be harnessed to treat all cancers, say scientists.

(Top right) Antigen escape: tumor cells can downregulate or lose the ... This strategy fosters a proinflammatory environment within tumor tissue, enhancing immune activation and amplifying antitumor ...

The group has established a platform to combine the study of human tissue specimens and mouse models of cancer to address key questions ranging from mechanisms of immune escape and treatment failures ...