Our original characterization of the Rip1 (Rv2869c) pathway in M. tuberculosis revealed that this S2P is a critical virulence determinant. We have identified four anti-Sigma factor substrates of Rip1, ...

Otsuka Corporation is at present evaluating its nitroimidazo-oxazole, OPC-67683, and the TB Alliance is evaluating the nitroimidazo-oxazine PA-824, originally discovered at Pathogenesis and ...

Several strengths of the analysis deserve comment. We considered the effect of HIV infection on TB pathogenesis, and accounted for survival with asymptomatic HIV and clinical AIDS, since HIV ...

A 40-year-old man presented to the emergency department with a 5-day history of fevers, sore throat, fatigue, subjective ...

“When we treat TB, we're not treating one disease, but really several manifestations of that disease,” says Stewart Cole, Professor and Chair of Microbial Pathogenesis and Director of the ...

Tuberculosis: Examining the influence of epidemiological risk factors, host genetics, microbial genetics, and host immunology on thd development of latent M. tuberculosis infection and active TB ...

Every two minutes one person dies of the disease in India, according to the WHO In 2018, India set for itself the lofty goal of eliminating pulmonary tuberculosis (TB) by 2025 - five years ahead ...

After entry, the offending organism secretes pyrogenic exotoxin A, beginning a cascade of events leading to eventual tissue destruction. Exotoxin A stimulates the production of cytokines, damaging ...

University of Arkansas at Little Rock researcher Lu Huang, Ph.D., has received a $3.7 million grant from the National ...

The facility has been specifically designed to support cutting edge immunologic and microbiome research that will elucidate the pathophysiology of HIV-TB co-infection and inform the development of ...