Most cancer treatments – from chemotherapies to engineered immune cells – have a host of side effects, in large part because they affect healthy cells in the body at the same time as targeting tumor ...

Engineered receptors could lead to more precisely targeted, effective cancer therapies with fewer side effects than existing ...

For instance, nuclear mediator of RNA polymerase II transcription subunit 12 activates TGF beta signaling and activates the expression of TGF beta target genes like vimentin; this promotes ...

Prostaglandin E 2-EP2/EP4 signaling induces immunosuppression in human cancer by impairing bioenergetics and ribosome biogenesis in immune cells Mechanisms of prostaglandin E2 (PGE2)-mediated ...

3- Kindlin-2 as a major regulator of the oncogenic signaling of TGF-β and cancer cell senescence: We also established Kindlin-2 as a major player in the modulation of the tumor microenvironment by ...

Traditional Chinese Medicine (TCM) is a holistic approach to treating a person’s mental and physical health problems. It developed thousands of years ago, and its core practices have changed little ...

A new Review article series, “AI in Medicine,” explores the role of AI technology in clinical medicine and digital health, and examines the promise and pitfalls of its application across the ...

Additionally, all components of the TGF-β Dauer signaling pathway are required for the activation of systemic UPR mt. Further investigations revealed that inhibiting daf-7 function in just a pair ...

hen Indonesian President Prabowo Subianto becomes the leader of Southeast Asia’s largest economy on Oct. 20, the former defense minister will take the reins of a Group of 20 nation brimming with ...

8 Beijing Institute of Hepatology, Beijing You’an Hospital, Capital Medical University, Beijing, People's Republic of China Conclusion Our findings underscore the hepatoprotective effect of ECM1, ...