Most cancer treatments – from chemotherapies to engineered immune cells – have a host of side effects, in large part because they affect healthy cells in the body at the same time as targeting tumor ...

Engineered receptors could lead to more precisely targeted, effective cancer therapies with fewer side effects than existing ...

This work is an important contribution to understanding the role of FGF signaling in the induction of primitive-like cells in a 2D system of human gastrulation. The authors provide compelling evidence ...

For instance, nuclear mediator of RNA polymerase II transcription subunit 12 activates TGF beta signaling and activates the expression of TGF beta target genes like vimentin; this promotes ...

3- Kindlin-2 as a major regulator of the oncogenic signaling of TGF-β and cancer cell senescence: We also established Kindlin-2 as a major player in the modulation of the tumor microenvironment by ...

1 Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine ... as well as the anti-inflammatory factors IL10 and TGFB. The results indicated that RIG012 ...

Traditional Chinese Medicine (TCM) is a holistic approach to treating a person’s mental and physical health problems. It developed thousands of years ago, and its core practices have changed little ...

Additionally, all components of the TGF-β Dauer signaling pathway are required for the activation of systemic UPR mt. Further investigations revealed that inhibiting daf-7 function in just a pair ...

hen Indonesian President Prabowo Subianto becomes the leader of Southeast Asia’s largest economy on Oct. 20, the former defense minister will take the reins of a Group of 20 nation brimming with ...

1 State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas Scientists of Organ Fibrosis, College of ...