The spatiotemporal transition of small GTPase Rab5 to Rab7 is crucial for early-to-late endosome maturation, yet the precise mechanism governing Rab5-to-Rab7 switching remains elusive. USP8, a ...

PEG has to shed from the nanoparticles to allow close interaction with the tumor cells. Current strategies for facilitating endosome escape, such as ion pair formation, “proton sponge effect”, ...

A Python-based module for creating flexible and robust spike sorting pipelines.

Our new trackers BoT-SORT, and BoT-SORT-ReID rank first in the datasets of MOTChallenge [29, 11] on both MOT17 and MOT20 test sets, in terms of all the main MOT metrics: MOTA, IDF1, and HOTA. For ...

Internalized cargo are shuttled through a maze of intracellular sorting and transport stations until they reach their destinations. Primary endocytic vesicles fuse with early endosomes ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Extracellular vesicles (EVs) are cell-secreted lipid bilayer delimited particles that ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Lipid droplets (LDs) serve as crucial hubs for ...