Elevated leptin levels trigger insulin resistance by activating pro-inflammatory pathways that induce mitochondrial ...

Recent data indicate that these molecules are also integral players in coordinating defence mechanisms in the innate immune system. In this respect, PI3K and mTOR positively regulate immune cell ...

However, this company is looking to change the scope of PI3K-alpha [PI3Ka] targeting by going after specific mutation types while sparring wild-type enzyme in healthy human tissues. It believes ...

Expert Rev Clin Pharmacol. 2012;5(3):319-336. Finally, a recent study suggested that although prasugrel significantly reduces thrombotic events in patients with ACS undergoing PCI because of its ...

Functional analyses support that this mutation specifically impairs Nef`s ability to stimulate PI3K/Akt/mTORC2 signalling. This important study suggests that the accessory viral Nef protein impairs B ...

aDepartment of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States bRobert and Arlene Kogod Center on Aging, Mayo Clinic, 200 ...

From the largest to the smallest, the degrees of pathways were PI3K-Akt signaling pathway, HIF-1 signaling pathway ... The intervention of CBD can reduce the level of oxidative stress and inflammatory ...

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Additionally, the cytoskeleton regulates signaling pathways like TGF-β, Wnt, and PI3K/Akt, which are pivotal in the fibrotic process. Future therapeutic strategies should focus on targeting ...