Dr Zain Hasan is an anesthesiologist based out of California. He says everything from pain killers to chemo drugs could ...

Scientists are looking at a range of different drug classes, such as lysyl oxidase (LOX) inhibitors and NADPH-oxidase inhibitors – but an obvious choice is a class of drugs known as autotaxin ...

As the main site for ROS production, maintaining mitochondrial integrity is vital for cardiac health. Cardiac tissues generate ROS through mechanisms involving NADPH oxidase, xanthine oxidase, and ...

Objective: This study aimed to investigate the neuroprotective effects of ANPCD on oxidative stress and neuronal apoptosis after ICH by targeting the receptor for advanced glycation end products (RAGE ...

It is a small molecule that is administered through oral route as capsule formulation. It acts by targeting pan-NADPH oxidase (NOX). The drug candidate is developed based on high throughout NOX ...

The proposed mechanisms of action of some of the nutraceutical supplements on the mammalian cholesterol pathway are shown in Figure 2. Virtually all studies have shown very high safety profiles ...

Peroxynitrite induces cell death, and can influence signal-transduction processes, mitochondrial function and signalling of apoptosis. The formation and reactions of peroxynitrite play a ...

心脑血管疾病是全球范围内导致死亡的主要原因之一，共占全球死亡人数的21.6%（每年34万人）[1]。在西方社会，动脉粥样硬化和相关心血管疾病仍然是最常见的死亡和发病原因，超过10%的心血管死亡被认为是由吸烟引起的[2]。许多流行病学研究已经对吸烟与动 ...

Future Microbiol. 2012;7(6):719-731.

This month's cover highlights the article An octameric PqiC toroid stabilises the outer-membrane interaction of the PqiABC transport system by Benjamin Cooper, Timothy Knowles, and colleagues. The ...