The stressed neurons spurred surrounding glia to crank up production of lipid droplets. When they overexpressed tau in glia, but not in photoreceptor neurons, lipid droplet production fell by nearly ...

The central organelle within the hepatocyte that stores excess fat is the lipid droplet (LD). Scores of different proteins control the formation and use of LDs. A deficit in LD breakdown is believed ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Lipid droplets (LDs) serve as crucial hubs for ...

Specifically, unsaturated FAs, including linoleic acids (LA), activate the FABP4/CEBPα pathway, leading to triglyceride synthesis and lipid droplet formation. Furthermore, FABP4 enhances lipolysis and ...

The authors conclude that unsaturated fatty acids are transported into macrophages by the chaperone FABP4 where they induce C/EBPalpha expression and transcriptional activity resulting in upregulation ...

Notably, resident microglia and infiltrating neutrophils exhibit swift responses during the initial phase of injury, while peripheral monocyte-derived macrophages exhibit transcriptomic profiles akin ...

Aug. 14, 2024 — More than a quarter of Australians over the age of 50 take cholesterol-lowering drugs to prevent heart disease and strokes, but our bodies also need cholesterol to survive.

1 School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China 2 Department of Orthopedics, Chengdu Integrated Traditional Chinese Medicine & Western ...