Consequently, an immunosuppressed and immune-tolerant TME promotes cancer cell proliferation and metastasis. Long non-coding RNAs (lncRNAs), a category of non-coding RNA longer than 200 nucleotides, ...

National Nanfan Research Institute (Sanya), Chinese Academy of Agricultural Sciences, Sanya 572024, Hainan, China ...

Univ. Lille, Inserm, CHU Lille, U1286─INFINITE─Institute for Translational Research in Inflammation, Lille F-59000, France ...

Their study revealed that, beyond inhibiting tumor growth, metformin uniquely impacted immune pathways ... to immune system activity and cancer cell signaling. This indicates that metformin ...

Drug sensitivity analysis highlights the effects of imatinib and metformin, revealing metformin’s unique role in modulating immune pathways ... activity and cancer cell signaling.

Both Wnt and BMP signaling regulate maintenance of Lgr5 + intestinal stem cells, but their interplay remains incompletely understood. This study shows that the BMP-suppressed chromatin regulator ...

Apart from the above pathophysiological roles, lactylation also played a pivotal role in cell fate determination and embryonic development (Li et ... Downregulated CircXRN2 activates the Hippo ...

RNA sequencing of treated mesoderm explants revealed downregulation of pathways involved in cell migration and extracellular matrix interactions when glycolysis or ERK signaling was inhibited.