Besides, the interaction between lncRNA and the miRNA–PD-L1/PD-L2 axis were verified by dual luciferase reporter assay. Conclusion: LINC01094 dually regulates the expression of PD-L1 and PD-L2 and ...

Aquaporins (AQPs), a family of membrane proteins that facilitate the transport of water and small solutes, have garnered increasing attention for their role in sepsis, not only in fluid balance but ...

During the peer-review process the editor and reviewers write an eLife assessment that summarises the significance of the findings reported in the article (on a scale ranging from landmark to useful) ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Increased H3K27ac levels upon tumor ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Hormone therapy resistance and the ensuing ...

When students become active doers of mathematics, the greatest gains of their mathematical thinking can be realized. The process of sense making begins when we create classrooms full of curious ...

人类遗传学的一个紧迫问题是了解这些非编码的基因组区域的作用，实际上，这些区域虽然不编码蛋白质，但它们广泛转录为RNA，其中包括成千上万的长链非编码RNA（lncRNA），这些lncRNA通常被剪接和多聚腺苷酸化，但通常不能翻译成蛋白质。在已注释的lncRNA中 ...

长链非编码RNA（long non-coding RNA，lncRNA）是长于200个核苷酸的大型RNA转录物，在人类转录组中表达的基因中，超过68%转录为lncRNA，近年来，lncRNA编码的微蛋白质的翻译潜能的揭示，为深入探究癌症及其他疾病的发生与进展机制开辟了崭新的研究视野，然而目前在 ...