This study confirmed the efficacy and tolerability of initial use of a fixed combination of losartan/hydrochlorothiazide vs. losartan without a thiazide. The possible limitations of the stepped ...

After 6 weeks, significantly more patients reached goal BP after one titration step of combination therapy vs ... 4, and 6. Losartan/HCTZ: Week 2, n=393; Week 4, n=392; Week 6, n=368; losartan ...