Liver hepatocyte organoids derived from normal (left) or mutant (right) mice showing accumulation of lipids (in green). Higher levels of lipids accumulate as big droplets inside each cell (nuclei ...

However, prolonged metabolic stress allows once-senescent liver cells to start dividing and progress to cancer.

Intestines suffer a lot of wear and tear in their daily service to digestion, requiring constant renewal of their lining.