The following is a summary of "Comparison of first-line chemotherapy regimens in unresectable locally advanced or metastatic ...

A liposomal irinotecan formulation has been shown to have multimechanistic activity: Cytotoxic activity against tumor cells with demonstrated efficacy in a wide range of animal xenograft models.

The results of the NAPOLI-3 study of Onivyde (liposomal irinotecan) as part of a combination regimen with 5-fluorouracil (5-FU), leucovorin, and oxaliplatin showed an improvement in overall ...