Human cell transformation systems revealed that RAL-GEF signaling is particularly required for oncogenic RAS function in human cancer. Murine Kras-driven lung cancer models have confirmed the key ...

Next, using two mouse models of KRAS-driven lung cancer, investigators inactivated ... the spatial precision facilitated by ...

This suggests a model in which lung damage from smoking or ... There are multiple cancer drugs that specifically target mutated KRAS, but these mostly deliver only limited clinical benefit.

KRAS G12C is the most common form of KRAS mutation in lung cancer, while G12D is found more commonly in other diseases like pancreatic and colorectal cancers. Dr Hu Tao, co-founder and chief ...

the team used a model with tobacco carcinogen exposure, which creates lung damage like that incurred by cigarette smoke. They ...

A new collaborative study from Karolinska Institutet published in Science Advances shows that the levels of mitochondrial DNA ...

The MHRA has approved Lumykras (sotorasib) for patients with previously treated locally advanced or metastatic non-small cell lung cancer (NSCLC) with the KRAS G12C mutation, and according to ...

The research will test immunotherapies – treatments that harness the power of our immune system – to treat patients with a specific kind of lung cancer (KRAS-mutant), which is particularly ...

Roche also axed a trial for divarasib, specifically a phase 2/3 trial that was comparing the KRAS G12C inhibitor to docetaxel in the second-line treatment of non-small cell lung cancer (NSCLC).

Current and former smokers are to be invited to the country’s first mobile lung health check, which aims to improve the early detection of lung cancer.