Murine Kras-driven lung cancer models have confirmed the key requirements for RAF, PI3K and RAL-GEF in vivo. Co-opted pathways required by oncogenic KRAS in order to sustain lung tumorigenesis ...

This suggests a model in which lung damage from smoking or ... There are multiple cancer drugs that specifically target mutated KRAS, but these mostly deliver only limited clinical benefit.

Murine Kras-driven lung cancer models have confirmed the key requirements for RAF, PI3K and RAL-GEF in vivo. Co-opted pathways required by oncogenic KRAS in order to sustain lung tumorigenesis ...

Although activating KRAS mutations occur frequently in cancer, targeting this oncogene has proved difficult. Three groups have now identified pathways that have not been previously linked to KRAS ...

Merck & Co’s Keytruda reigns supreme among immunotherapies for non-small cell lung cancer (NSCLC), and new data looks set to consolidate that position even further with new data in KRAS-positive ...

Next, using two mouse models of KRAS-driven lung cancer, investigators inactivated HDAC3 and observed enhanced T-cell ...

They hypothesized that smoking, which is causally related to lung cancer ... expressed signatures of KRAS activation. Indeed, ...

KRAS G12C is the most common form of KRAS mutation in lung cancer, while G12D is found more commonly in other diseases like pancreatic and colorectal cancers. Dr Hu Tao, co-founder and chief ...

We approach this question using a combination of sophisticated genetically engineered mouse models, single-cell approaches ... cell where they came from — one that might be exploited to make an ...

A new collaborative study from Karolinska Institutet published in Science Advances shows that the levels of mitochondrial DNA ...

ALTA3263 induced complete and sustained tumor regressions in 8 KRAS G12V/D/C/A mutant xenograft models, including complete responses in 2 patient-derived xenograft non-small cell lung cancer ...

studied the impact of KRAS on tumour initiation, progression, and therapeutic response in pancreatic and colorectal cancers using both mouse models and patient data. Published in Cancer Research ...