Tophi are firm, painless yellow lesions that form in and around the joints in people with advanced gout. They have a uric acid (monosodium urate) core, and the skin that covers them can become ...

These decrements in HRQOL vary across the spectrum of clinical phenotypes according to the presence and frequency of gout symptoms and signs. Patients with confirmed tophi and more frequent acute ...

Gout patients frequently have a number of comorbidities, including obesity, hypertension, high serum lipid and cholesterol levels, kidney disease, diabetes, and cardiovascular disease. [2,7,19 ...

Objective To identify methods of tophus measurement for gout studies, summarise the properties of these methods and compile a detailed pictorial reference guide to demonstrate the methods. Methods A ...

sUA levels above its saturation point result in the deposition of monosodium urate crystals, which lead to gout flares and tophi (1). Multiple studies support the use of sUA levels as a marker for ...

Untreated gout places a substantial burden on the global health system, as chronic gout causes tophi formation, chronic joint ...

Gout affects around 9 million Americans, and around 50% of those with gout will have their first attacks begin in the big toe. The severity of gout will depend on the individual, but, on average ...

Knee pain at night is a common condition caused by injury, arthritis, bursitis, gout, and more. When it happens at bedtime, it can also lead to insomnia, which can leave you exhausted during the day.

Severe gout was defined by the presence of 5 or more tophi. The mechanisms of generalized neuropathy remain unclear and likely involve multiple factors. Patients with gout and neuropathic symptoms ...

Gout sounds like a disease that shouldn’t exist ... Uric acid forms crystals around joints in the body, most commonly in the big toe or knee, but can be found in any joint.

Significant differences in gout duration, number of urate arthropathies, serum urate (SU) levels, tophi, blood urea nitrogen (BUN), serum creatinine (sCr), and estimated glomerular filtration rate ...