Colorectal cancers, which kill more than 900,000 people each year, are notoriously heterogeneous. The cell type and the genetic mutations that give rise to the tumors and the effect of the tumor ...

During the study, investigators derived proximal and distal colon organoids from 2-month-old mice and introduced the BRAF cancer-causing gene. Organoids are lab-grown clusters of cells that ...

Tongue cancer (TC) cells can enter a chemo-resistant state by activating pathways related to autophagy and cholesterol synthesis, report researchers. Using a large-scale library of TC organoids ...

University of Wisconsin–Madison researchers revealed how gut microbial bile acids impact colon cancer. One bile acid slows tumor growth by supporting the FXR protein, while another accelerates cancer ...

Instead of trying to establish cancer cell lines, they built a large-scale library of tongue cancer organoids (TCOs) from surgery samples of 28 patients. Organoids are three-dimensional tissue models ...