During the study, investigators derived proximal and distal colon organoids from 2-month-old mice and introduced the BRAF cancer-causing gene. Organoids are lab-grown clusters of cells that ...

Colorectal cancer (CRC ... Here the authors model the CRC subtypes with genetically engineered mouse organoids, identify the metabolic signature of CMS3 is driven by enterocyte-like ...

Findings from mouse models and human organoids offer pathways for early detection and new targeted therapies for colorectal cancer. Microbial Bile Acids’ Dual Roles: Two bile acids modified by gut ...

Colorectal cancers, which kill more than 900,000 people each year, are notoriously heterogeneous. The cell type and the genetic mutations that give rise to the tumors and the effect of the tumor ...

Tongue cancer (TC) cells can enter a chemo-resistant state by activating pathways related to autophagy and cholesterol synthesis, report researchers. Using a large-scale library of TC organoids they ...

Researchers from the Organoid group at the Hubrecht Institute have developed a new way to grow organoids. Organoids are tiny organs that are grown in the lab and mimic the original organ.

Scientists grow organ-specific stem cells in vitro using 3D cell culture technology to produce organoids, miniature organ models that provide valuable insight into tissue development. Researchers ...