Not only have researchers identified how a common cellular protein affects aging, but they’ve tweaked the genes that produce ...

受限于罕见肿瘤样本，特定疾病动物模型不易得的困境，使该类疾病的发病机制和治疗方案研究难以得到有效进展，面临“巧妇难无米之炊”的窘境。同时，对于一些慢性复杂疾病，小鼠或细胞模型机制与实际临床疾病的一致性较差，导致在临床中发现的机制靶点难以在小鼠或细胞模 ...

Buildup of a protein called filamentous actin, or F-actin, in the brain inhibits the removal of cellular wastes, including DNA, lipids, proteins and organelles. The resulting accumulation of waste ...

The compelling evidence explains how Rab8 family members bind at two sites to allosterically regulate MICAL1, and relieve an auto-inhibited state unable to bind actin. This study lays the basis for ...

When forces are applied in a specific direction, vinculin forms stronger bonds with actin filaments, much like the latch securing the boat. However, when forces come from other directions ...

The actin cytoskeleton is the network of proteins bound together in filaments that determine a cell's shape and enables cellular movement and division. "I initially thought that lifetime exposure ...

ATP is needed in the body to breakdown the actin-myosin filaments in the muscle fibers. These filaments are what contract and ...