BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a major health concern. Pathological stimuli and interactions between cardiac fibroblasts (CFs) and other cell types may lead to ...

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Mitochondrial dysfunction is a key factor in the development of atherogenesis. METTL4 (methyltransferase-like protein 4) mediates N6- methyldeoxyadenosine (6mA) of mammalian mitochondrial DNA (mtDNA).

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Our understanding of hypertension and the ability to lower blood pressure (BP) with pharmacotherapy advanced immensely during the second half of the 20th century and the early 21st century. However, ...

Our vision is to innovate and incorporate promising technologies to communicate freely available, high-priority, high-quality content, which accelerates scientific progress and advances heart and ...

Figure 1. Age-standardized stroke disability-adjusted life-years (DALYs) and mortality rates per 100,000 person-years in various regions of the world in 2013 (both sexes, all ages) Although stroke ...

In the current issue of Circulation, Mehta and colleagues compared 1-year saphenous vein graft failure (defined as ≥75% angiographic stenosis or occlusion) and 5-year clinical events (composite of ...

Department of Physiology and Cardiothoracic Surgery, Cardiovascular R&D Centre – UnIC@RISE, Faculty of Medicine of the University of Porto, Portugal (J.P.F.). Heart Failure Clinic, Internal Medicine ...

Myocardial infarction (MI) is a complex disease caused by both lifestyle and genetic factors. This study aims to investigate the predictive value of genetic risk, in addition to traditional ...

Heart failure with preserved ejection fraction (HFpEF) is a major public health problem characterized by multiple simultaneous comorbidities whose specific contribution is challenging to disentangle ...