To understand the workings of DNA in relation to disease, scientists at Los Alamos National Laboratory have developed the ...

The answer lies in transcription factors. Experiments have shown that ... believed to be part of the activation process. Chromatin structure allows activators to associate with one another ...

Mediator—a general transcription factor—may acquire gene-specific functions that are triggered by TF binding. One focus of the lab is to study how TFs regulate Mediator structure and function. To do ...

Since the 2023 financing round, Flare’s lead program FX-909 has moved into a phase 1 clinical trial for patients with ...

Professor Carsten Carlberg has published a comprehensive new textbook, "Gene Regulation and Epigenetics: How Science Works," ...

A) The structure of TLRs is characteristic of ... The final targets of TLRs are DNA-binding transcription factors (such as NF-kB and IRFs) that activate specific patterns of gene expression ...

Michael Erb, a chemical biologist at Scripps Research and coauthor on the paper, tells C&EN that transcription factors were previously considered undruggable because they “don’t have the types ...

TBP binding to the TATA-box nucleates PIC formation either through a stepwise assembly of other basal transcription factors or through recruitment ... we determined the 2.65-Å resolution crystal ...

A representation of transcription factor proteins binding to a strand of DNA. Courtesy LANLLANL NEWS RELEASE To understand ...