These TF-specific structural states may direct gene-specific regulatory events; in other words, Mediator—a general transcription factor—may acquire gene-specific functions that are triggered by TF ...

Transcription factors are proteins involved in the process of converting, or transcribing, DNA into RNA. Transcription factors include a wide number of proteins, excluding RNA polymerase ...

To understand the workings of DNA in relation to disease, scientists at Los Alamos National Laboratory have developed the ...

Since the 2023 financing round, Flare’s lead program FX-909 has moved into a phase 1 clinical trial for patients with ...

TBP binding to the TATA-box nucleates PIC formation either through a stepwise assembly of other basal transcription factors or through recruitment of a pre-assembled Pol ... we determined the 2.65-Å ...

BEN-solo factors partition active chromatin to ensure proper gene activation in Drosophila. Nature Communications 10: 5700. (*, co-corresponding authors). Dai Q, Ren A, Westholm JO, Duan H, Patel DJ ...

Professor Carsten Carlberg has published a comprehensive new textbook, "Gene Regulation and Epigenetics: How Science Works," ...

A representation of transcription factor proteins binding to a strand of DNA. Courtesy LANLLANL NEWS RELEASE To understand the workings of DNA in relation to disease, scientists at Los Alamos ...

Michael Erb, a chemical biologist at Scripps Research and coauthor on the paper, tells C&EN that transcription factors were previously considered undruggable because they “don’t have the types ...