In the early 20th century, researchers mainly used mice to study cancer. They found that they could only transmit cancer to mice that had a specific mutation but not to animals lacking the mutation.
The newly reported studies demonstrated that the antibodies, in a T cell engager format, can effectively kill cancer cells expressing relevant HER2 mutations both in vitro, and in a mouse ...
Researchers from Congruence Therapeutics Inc. have described the development of a mouse model of genetic obesity with a clinically relevant, naturally occurring human melanocortin MC4 receptor (MC4R) ...
A mouse model was used to investigate the functional consequences of the rs374152717 mutation. Mice carrying the human mutation exhibited low bone mass, a hallmark of osteoporosis, which the ...