The mechanisms by which cell polarity is translated into segregation ... evidence indicates that spindle positioning is mediated by microtubule depolymerization and dynein function, as well ...

During anaphase, the central region of the microtubule spindle reorganizes to produce the midzone — an array of antiparallel microtubules essential for cell division. Two studies in Cell have ...

Their findings, published in Developmental Cell, shed light on how a protein called CDK5RAP2 activates the microtubule nucleator γ-tubulin ring complex (γTuRC), a key component of this skeleton ...

Judging from their organization, they would be important in the function of creating the microtubule organization ... have suggested that APC at the cytoplasmic surface of membranes is involved in ...

Adhesion junction is crucial for the stability of the epithelial lateral membrane and the maintenance of cell polarity. E-cadherin is an essential cell-cell adhesion protein, with the canonical E ...

and disrupted neuronal polarity can cause disease. For example the mis-localization of the microtubule-associated protein, tau, and of the transmembrane protein beta-amyloid is thought to contribute ...