The stressed neurons spurred surrounding glia to crank up production of lipid droplets. When they overexpressed tau in glia, but not in photoreceptor neurons, lipid droplet production fell by nearly ...

These images show microglia containing lipid droplets (white spots). Researchers at UC San Diego have revealed that in brains with Alzheimer’s and related diseases, neurons offload excess lipid ...

Arlt H, Sui X, Folger B, Adams C, Chen X, Remme R, Hamprecht FA, DiMaio F, Liao M, Goodman JM, Farese RV Jr, Walther TC. Seipin forms a flexible cage at lipid droplet formation sites. Nat Struct Mol ...

Oil droplet formation: Oil (yellow) accumulates between the layers of the membrane that forms the endoplasmic reticulum (ER)—a network of membranes within the cytoplasm of plant cells.

As a result, other brain cells, called microglia ... APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size, Journal of Cell Biology (2024).