Human cell transformation systems revealed that RAL-GEF signaling is particularly required for oncogenic RAS function in human cancer. Murine Kras-driven lung cancer models have confirmed the key ...

Next, using two mouse models of KRAS-driven lung cancer, investigators inactivated ... the spatial precision facilitated by ...

Merck & Co’s Keytruda reigns supreme among immunotherapies for non-small cell lung cancer (NSCLC), and new data looks set to consolidate that position even further with new data in KRAS-positive ...

This suggests a model in which lung damage from smoking or ... There are multiple cancer drugs that specifically target mutated KRAS, but these mostly deliver only limited clinical benefit.

Learn about research at MSK that finds obesity can influence driver mutations that produce specific subtypes of cancers, ...

KRAS G12C is the most common form of KRAS mutation in lung cancer, while G12D is found more commonly in other diseases like pancreatic and colorectal cancers. Dr Hu Tao, co-founder and chief ...

the team used a model with tobacco carcinogen exposure, which creates lung damage like that incurred by cigarette smoke. They ...

A new collaborative study from Karolinska Institutet published in Science Advances shows that the levels of mitochondrial DNA ...

KRAS, a gene known to be mutated in various cancers, has effects that are more complex than previously understood. While the role of cancer-driving, mutated forms of KRAS is well-known, this new ...

Current and former smokers are to be invited to the country’s first mobile lung health check, which aims to improve the early detection of lung cancer.

Recent research from the University of Helsinki sheds new light on the behavior of the KRAS gene in two of the deadliest cancers—pancreatic and colorectal cancer. These findings suggest ...

Human cell transformation systems revealed that RAL-GEF signaling is particularly required for oncogenic RAS function in human cancer. Murine Kras-driven lung cancer models have confirmed the key ...