In conclusion, this intriguing report builds on the work of many other groups by further unraveling MECP2 function in the ...

For example, activated T helper type 1 lymphocytes secrete interferon (IFN)-γ, which has potent effects on osteoclastogenesis in vivo and in vitro. IFN-γ, however, is known to cause both bone ...

Both novel bifunctional (SON-1411) and monofunctional (SON-1400) fusion proteins exhibit wild-type binding to the IL-18 ...

Detection was highly specific for IFN-γ, with minimal response observed only when exposed to exceedingly high levels of IFN-α or IFN-β, two other interferon types. Further in vitro assays showed that ...

Clinical improvement was associated with reduced leukocyte infiltration and interferon-γ production, which predicted a sustained response to apheresis. The authors speculate that apheresis could ...