Colorectal cancers, which kill more than 900,000 people each year, are notoriously heterogeneous. The cell type and the genetic mutations that give rise to the tumors and the effect of the tumor ...

Organoids are lab-grown clusters of cells that resemble specific organs, such as the colon, and can grow indefinitely. They mimic the stem cell and differentiation patterns of the original tissue ...

Using a large-scale library of TC organoids they developed, the researchers performed comprehensive comparative analyses of chemo-sensitive and chemo-resistant cells. Their efforts shed light on ...

Biopsies of 71 patients with advanced colorectal cancer were taken and then grown into miniature 3D cancerous organs in the laboratory. Growing "organoids" is a relatively new scientific technique ...

We've now identified a molecule that can help the intestines to heal after damage while suppressing tumor growth in colorectal cancer ... what are known as 3D organoids: small, three-dimensional ...

They biopsied the colon to obtain tissue specimens grown into organoids. This collection of organoids is a biobank that ...

University of Wisconsin–Madison researchers revealed how gut microbial bile acids impact colon cancer. One bile acid slows tumor growth by supporting the FXR protein, while another accelerates cancer ...

Instead of trying to establish cancer cell lines, they built a large-scale library of tongue cancer organoids (TCOs) from surgery samples of 28 patients. Organoids are three-dimensional tissue models ...

Organoids are cell culture models that functionally resemble an organ. They have the potential to speed up drug development, improve understanding of disease treatment in diverse populations ...