ahajournals.org6d
YAP Overcomes Mechanical Barriers to Induce Mitotic Rounding and Adult Cardiomyocyte Division
BACKGROUND: Many specialized cells in adult organs acquire a state of cell cycle arrest and quiescence through unknown ...
BMJ2mon
7 Runx1 deficiency protects against adverse cardiac remodelling following myocardial infarction
Our objective is to answer the question – is Runx1 merely a marker of cardiomyocyte damage or does it play a significant functional role post-MI? Conclusion Runx1 is a new target with therapeutic ...
eLife9y
Reduced matrix rigidity promotes neonatal cardiomyocyte dedifferentiation, proliferation and clonal expansion
Cardiomyocyte (CM) maturation in mammals is accompanied by ... CM mitotic rounding and cell division (cytokinesis), associated with loss of differentiation markers. Moreover, the compliant matrix ...
eLife20d
Human induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient
Treatment with both TNF-α and IFN-γ resulted in a significant increase in decay time and downstroke time, which are markers of cardiomyocyte relaxation, while beats per minute (indirect measurement of ...