Under this two-hit model, Brugge says, one normal copy of BRCA1 ought to be able to carry out DNA repair even when the other ...

Research shows that the breast cancer gene 1 (BRCA1) not only pushes accurate DNA repair to guard against cancer but promotes subsequent activity in tumor suppression. A new study led by The ...

Research led by The University of Texas Health Science Center at San Antonio shows that the breast cancer gene 1 (BRCA1) not only pushes accurate DNA repair to guard against cancer but promotes ...

A new study in mice explains how even a single faulty copy of the BRCA1 gene can fuel tumor growth. The findings suggest the dominant “two-hit” hypothesis of cancer development may not tell the full ...

University of Oregon biologists have uncovered a mechanism by which a well-known breast cancer gene also influences fertility ...

Figure 1: Deletion of exon 11 of Brca1 from mouse germ line. Figure 4: Effects of Brca1-Δ11 mutation on gene expression, tumorigenesis, cell survival and proliferation, and G 1 –S cell cycle ...

TOP1 is the target of topotecan, which was approved in 1997 by the U.S. Food and Drug Administration (FDA) to treat relapsed ...

前列腺癌是一种具有高度遗传性的癌症，据估计约40%～50%的前列腺癌与遗传因素相关。流行病学和家系研究证实前列腺癌有明显的家族聚集性，在这些家族性前列腺癌中，遗传因素扮演了尤为重要的角色。目前已证实多个DNA损伤修复基因的胚系突变与前列腺癌遗传易感相关。以BRCA1和BRCA2为代表的DNA损伤修复基因是迄今为止认识最充 ...

The new research led by UT Health San Antonio shows that BRCA1 not only pushes a DNA break toward an accurate DNA repair mechanism called homologous recombination (HR) but also promotes subsequent ...

People inherit two copies of each gene — one from each parent — an evolutionary fail-safe to ensure survival even when one of ...

The product of a sixth, newly-cloned FA-associated gene has been linked to BRCA1, and may finally offer ... since in wild-type cells it was induced by DNA damaging agents in a time- and dose ...

Of the 28 patients, nine had tumors with BRCA1 alterations, 16 had BRCA2 alterations and three had both BRCA1 and BRCA2 alterations. Additionally, 64% of patients had tumors with coalterations and at ...