TOP1 is the target of topotecan, which was approved in 1997 by the U.S. Food and Drug Administration (FDA) to treat relapsed ...

Medically reviewed by Adam M. Brufsky, MD, PhD The exact cause or causes of triple-negative breast cancer are unknown, but ...

Researchers worked with two labs to identify 16 consensus lower-risk pathogenic variants and are pushing for greater ...

Cleveland Clinic researchers are presenting updated findings from their novel study of a vaccine aimed at preventing ...

Cleveland Clinic researchers are presenting updated findings from their novel study of a vaccine aimed at preventing ...

Researchers from the Walter and Eliza Hall Institute (WEHI)in Australia have found a new way to predict a subset of patients ...

Scientists pinpointed 80 gene variants, including eight tied to fatty acid metabolism, that may cause breast cancer in some ...

前列腺癌是一种具有高度遗传性的癌症，据估计约40%～50%的前列腺癌与遗传因素相关。流行病学和家系研究证实前列腺癌有明显的家族聚集性，在这些家族性前列腺癌中，遗传因素扮演了尤为重要的角色。目前已证实多个DNA损伤修复基因的胚系突变与前列腺癌遗传易感相关。以BRCA1和BRCA2为代表的DNA损伤修复基因是迄今为止认识最充 ...