A new study in mice explains how even a single faulty copy of the BRCA1 gene can fuel tumor growth. The findings suggest the dominant “two-hit” hypothesis of cancer development may not tell the full ...
Figure 1: Deletion of exon 11 of Brca1 from mouse germ line. Figure 4: Effects of Brca1-Δ11 mutation on gene expression, tumorigenesis, cell survival and proliferation, and G 1 –S cell cycle ...