Wetting and complex remodeling of membranes by biomolecular …
网页2023年5月22日 · Modulation of solution salinity or membrane composition drives the condensate-membrane system through two wetting transitions, from dewetting, through a broad regime of partial wetting, to...
Phase-separated droplets swim to their dissolution - Nature
网页2024年5月9日 · In cells, these condensates form membraneless organelles that can organize chemical reactions. However, little is known about the physical consequences of chemical activity in and around...
The Control Centers of Biomolecular Phase Separation: How Membrane …
网页2019年10月17日 · Membrane surfaces are emerging as essential regulatory platforms for the controlled assembly of biomolecular condensates. Specifically, membrane surfaces restrict the diffusion of proteins to two dimensions, reducing the threshold concentrations required for phase separation (Figure 2 A).
Phase Separation in Membrane Biology: The Interplay between Membrane …
网页2020年10月12日 · Phase separation of membrane-associated proteins participates in various trafficking events, such as clustering of vesicles for temporally controlled fusion and storage, and transport of membraneless condensates on membrane-bound organelles.
Biomolecular Condensates in Contact with Membranes
网页Recent years have witnessed growing evidence of the interaction of these droplets with membrane-bound cellular structures. Condensates’ adhesion to membranes can cause their mutual molding and regulation, and their interaction is of fundamental relevance to intracellular organization and communication, organelle remodeling, embryogenesis, and ...
Liquid phase condensation in cell physiology and disease | Science …
网页2017年9月22日 · Liquid phase condensation increasingly appears to be a fundamental mechanism for organizing intracellular space. Consistent with this concept, several membrane-less organelles have been shown to exhibit a concentration threshold for assembly, a hallmark of phase separation.
A framework for understanding the functions of biomolecular ... - Nature
网页2020年11月9日 · Experiments and theory demonstrate that membrane-associated condensates formed by endocytic coat and adaptor proteins can perform work to deform the membrane, as the balance of condensate ...
Considerations and challenges in studying liquid-liquid phase ...
网页2019年1月1日 · In cells, excess protein may be stored in membraneless organelles and will enter the dilute phase as needed when protein levels drop. LLPS can locally concentrate molecules in condensates to activate reactions, signaling processes and nucleation of cytoskeletal structures.
Condensation effect and transport on Alumina porous membranes
网页2024年9月25日 · Understanding the adsorption of water and characterizing the water film formed within nanostructures are essential for advancements in fields such as nanofluidics, water purification, and biosensing devices. In our research, we focus on studying the condensation and transport of water through an alumina membrane with nanopores of varying wettabilities. We introduce a method to alter the ...
Transitions in the framework of condensate biology - Cell Press
网页2023年4月6日 · Liquid-liquid phase separation (LLPS) underlies the formation of membrane-less compartments in cells. These compartments concentrate on a specific collection of proteins and nucleic acids and subsequently influence a myriad of biological events including but not limited to epigenetic regulation, transcription, and RNA metabolism.